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The main social event of the summer was a dance and reception. Main (meɪn) adj (prenominal) 1. Find 561 different ways to say main, along with antonyms, related words, and example sentences at thesaurus. com. The main thing is to keep calm and don’t get angry. The principal or most important part or point usually in the phrase in the main, mostly, chiefly How to use main in a sentence. The meaning of main is physical strength : Sheer or utmost (esp in the phrase by … Force —used in the phrase with might and main. Chief or principal in rank, importance, size, etc 2.